Reaction Details Report a problem with these data
Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM50154384
Substrate
n/a
Meas. Tech.
ChEMBL_1560760 (CHEMBL3778288)
EC50
144±n/a nM
Citation
 Tarver, JE; Pabba, PK; Barbosa, J; Han, Q; Gardyan, MW; Brommage, R; Thompson, AY; Schmidt, JM; Wilson, AG; He, W; Lombardo, VK; Carson, KG Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett 26:1525-8 (2016) [PubMed]  Article 
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM
Type:
PROTEIN
Mol. Mass.:
55706.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116492
Residue:
496
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
  
Inhibitor
Name:
BDBM50154384
Synonyms:
CHEMBL3774472
Type:
Small organic molecule
Emp. Form.:
C9H7BrN2O2S2
Mol. Mass.:
319.198
SMILES:
Cc1c(Br)sc2ncnc(SCC(O)=O)c12
Structure:
Search PDB for entries with ligand similarity: