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Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM50154398
Substrate
n/a
Meas. Tech.
ChEMBL_1560760 (CHEMBL3778288)
EC50
12±n/a nM
Citation
 Tarver, JE; Pabba, PK; Barbosa, J; Han, Q; Gardyan, MW; Brommage, R; Thompson, AY; Schmidt, JM; Wilson, AG; He, W; Lombardo, VK; Carson, KG Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett 26:1525-8 (2016) [PubMed]  Article 
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM
Type:
PROTEIN
Mol. Mass.:
55706.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116492
Residue:
496
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
  
Inhibitor
Name:
BDBM50154398
Synonyms:
CHEMBL3774864
Type:
Small organic molecule
Emp. Form.:
C12H9F3N2O2S2
Mol. Mass.:
334.337
SMILES:
OC(=O)CSc1ncnc2c(C3CC3)c(sc12)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: