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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50158396
Substrate
n/a
Meas. Tech.
ChEMBL_1564323 (CHEMBL3784644)
EC50
27±n/a nM
Citation
 Meena, CL; Thakur, A; Nandekar, PP; Sharma, SS; Sangamwar, AT; Jain, R Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. Eur J Med Chem 111:72-83 (2016) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R2 | Thyrotropin-releasing hormone receptor 2
Type:
PROTEIN
Mol. Mass.:
27545.04
Organism:
Mus musculus
Description:
ChEMBL_109850
Residue:
251
Sequence:
MDGPSNVSLVHGDTTLGLPEYKVVSVLLVLLVCTVGIVGNAMVVLVVLTSRDMHTPTNCYLVSLALADLIVLLAAGLPNVSDSLVGHWIYGHAGCLGITYFQYLGINVSSCSILAFTVERYIAICHPMRAQTVCTVARARRIIAGIWGVTSLYCLLWFFLVDLNVRDNQRLECGYKVSRGLYLPIYLLDFAVFFIAPLLGTLVLYGFIGRILFQSPLSQEAWQKERQSHGQSEGTPGNCSRSKSSMSSRKQ
  
Inhibitor
Name:
BDBM50158396
Synonyms:
CHEMBL3781773
Type:
Small organic molecule
Emp. Form.:
C23H27IN6O4
Mol. Mass.:
578.4028
SMILES:
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Structure:
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