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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM119758
Substrate
n/a
Meas. Tech.
ChEMBL_1566584 (CHEMBL3791478)
IC50
7±n/a nM
Citation
 Johansson, A; Löfberg, C; Antonsson, M; von Unge, S; Hayes, MA; Judkins, R; Ploj, K; Benthem, L; Lindén, D; Brodin, P; Wennerberg, M; Fredenwall, M; Li, L; Persson, J; Bergman, R; Pettersen, A; Gennemark, P; Hogner, A Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties. J Med Chem 59:2497-511 (2016) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
Gpr24 | MCHR1_MOUSE | Mchr1 | Slc1
Type:
PROTEIN
Mol. Mass.:
39133.74
Organism:
Mus musculus
Description:
ChEMBL_818502
Residue:
353
Sequence:
MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM119758
Synonyms:
US8685958, 7 | US8685958, 8
Type:
Small organic molecule
Emp. Form.:
C25H26N4O4
Mol. Mass.:
446.4983
SMILES:
O=C(N1CC(C1)Oc1ccc(CN2CC3(C2)CCOC3)cc1)c1nnc(o1)-c1ccccc1
Structure:
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