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Target
Metabotropic glutamate receptor 6
Ligand
BDBM17657
Substrate
n/a
Meas. Tech.
ChEMBL_1568371 (CHEMBL3789024)
EC50
65090±n/a nM
Citation
 Huynh, TH; Erichsen, MN; Tora, AS; Goudet, C; Sagot, E; Assaf, Z; Thomsen, C; Brodbeck, R; Stensbøl, TB; Bjørn-Yoshimoto, WE; Nielsen, B; Pin, JP; Gefflaut, T; Bunch, L New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. J Med Chem 59:914-24 (2016) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 6
Synonyms:
GRM6_RAT | Gprc1f | Grm6 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 6 (mGlu6) | Mglur6 | mGlu6 | metabotropic glutamate 6
Type:
Enzyme
Mol. Mass.:
95095.82
Organism:
Rattus norvegicus (Rat)
Description:
P35349
Residue:
871
Sequence:
MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
  
Inhibitor
Name:
BDBM17657
Synonyms:
(2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutamate | Glutamate | L-Glu | L-Glutamate | L-Glutamic acid | L-[14C(U)]glutamate | L-gluatmate
Type:
Amino Acid
Emp. Form.:
C5H9NO4
Mol. Mass.:
147.1293
SMILES:
N[C@@H](CCC(O)=O)C(O)=O
Structure:
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