Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50160598
Substrate
n/a
Meas. Tech.
ChEBML_1566194
EC50
>20000±n/a nM
Citation
 Xue, Y; Tang, J; Ma, X; Li, Q; Xie, B; Hao, Y; Jin, H; Wang, K; Zhang, G; Zhang, L; Zhang, L Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists. Eur J Med Chem 115:94-108 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50160598
Synonyms:
CHEMBL3787203
Type:
Small organic molecule
Emp. Form.:
C20H21N3OS
Mol. Mass.:
351.465
SMILES:
O=C(N[C@H]1CN2CCC1CC2)c1cc2ccc(cn2c1)-c1ccsc1 |r,wD:3.2,(4.83,-1.02,;4.2,.04,;4.95,1.38,;6.49,1.4,;7.29,0,;8.9,.01,;9.7,1.42,;8.88,2.83,;7.26,2.83,;7.37,1.54,;8.62,1.52,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;-3.71,1.53,;-5.1,.89,;-6.13,2.04,;-5.37,3.37,;-3.86,3.05,)|
Structure:
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