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Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50162270
Substrate
n/a
Meas. Tech.
ChEMBL_1572480 (CHEMBL3796340)
IC50
2.7±n/a nM
Citation
 Chen, X; Wang, K; Xu, W; Ma, Q; Chen, M; Du, L; Mo, M; Wang, Y; Shen, J Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema. J Med Chem 59:2674-87 (2016) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
  
Inhibitor
Name:
BDBM50162270
Synonyms:
CHEMBL3794054
Type:
Small organic molecule
Emp. Form.:
C23H20ClF4N3O4
Mol. Mass.:
513.869
SMILES:
Cn1c(cc(OCc2ccc(Oc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)nc1=O)N1CCOCC1
Structure:
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