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Target
Inward rectifier potassium channel 4
Ligand
BDBM162872
Substrate
n/a
Meas. Tech.
ChEMBL_1571192 (CHEMBL3795953)
IC50
>50000±n/a nM
Citation
 Walsh, SP; Shahripour, A; Tang, H; de Jesus, RK; Teumelsan, N; Zhu, Y; Frie, J; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Ehrhart, J; Roy, S; Kaczorowski, GJ; Yang, L; Garcia, ML; Pasternak, A Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation. Bioorg Med Chem Lett 26:2339-43 (2016) [PubMed]  Article 
Target
Name:
Inward rectifier potassium channel 4
Synonyms:
HIR | HIRK2 | HRK1 | Hippocampal inward rectifier | IRK-3 | IRK3 | Inward rectifier K(+) channel Kir2.3 | KCNJ4 | KCNJ4_HUMAN | Potassium channel, inwardly rectifying subfamily J member 4
Type:
PROTEIN
Mol. Mass.:
49496.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515519
Residue:
445
Sequence:
MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
  
Inhibitor
Name:
BDBM162872
Synonyms:
US9056859, 72
Type:
Small organic molecule
Emp. Form.:
C23H25N7O3
Mol. Mass.:
447.4897
SMILES:
Cc1c2COC(=O)c2ccc1CCN1CCN(CC1)C(=O)Cc1ccc(nc1)-n1cnnn1
Structure:
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