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Target
Cytochrome P450 2D6
Ligand
BDBM50166956
Substrate
n/a
Meas. Tech.
ChEMBL_1573500 (CHEMBL3801263)
IC50
>30000±n/a nM
Citation
 Gogliotti, RD; Engers, DW; Garcia-Barrantes, PM; Panarese, JD; Gentry, PR; Blobaum, AL; Morrison, RD; Daniels, JS; Thompson, AD; Jones, CK; Conn, PJ; Niswender, CM; Lindsley, CW; Hopkins, CR Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. Bioorg Med Chem Lett 26:2915-2919 (2016) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50166956
Synonyms:
CHEMBL3798517
Type:
Small organic molecule
Emp. Form.:
C18H16ClN5O2
Mol. Mass.:
369.805
SMILES:
CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1
Structure:
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