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Target
Integrase
Ligand
BDBM50170591
Substrate
n/a
Meas. Tech.
ChEMBL_1577821 (CHEMBL3808055)
IC50
2.0±n/a nM
Citation
 Velthuisen, EJ; Johns, BA; Temelkoff, DP; Brown, KW; Danehower, SC The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors. Eur J Med Chem 117:99-112 (2016) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50170591
Synonyms:
CHEMBL2403116
Type:
Small organic molecule
Emp. Form.:
C19H18FN3O5
Mol. Mass.:
387.3617
SMILES:
[H][C@]12Cn3cc(C(=O)NCc4ccc(F)cc4)c(=O)c(O)c3C(=O)N1CCCO2 |r|
Structure:
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