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Target
Caspase-3
Ligand
BDBM50171532
Substrate
n/a
Meas. Tech.
ChEMBL_1577039 (CHEMBL3807015)
IC50
487200±n/a nM
Citation
 Deng, CB; Li, J; Li, LY; Sun, FJ Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase. Bioorg Med Chem Lett 26:3195-201 (2016) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM50171532
Synonyms:
CHEMBL3805972
Type:
Small organic molecule
Emp. Form.:
C23H20N4O3
Mol. Mass.:
400.4299
SMILES:
COc1ccc(cc1)-c1ccc(C(=O)N\N=C2/C(=O)N(C)c3ccccc23)c(C)n1
Structure:
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