Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50176994
Substrate
n/a
Meas. Tech.
ChEBML_1582258
EC50
6000±n/a nM
Citation
 Schneider, P; Schneider, G De Novo Design at the Edge of Chaos. J Med Chem 59:4077-86 (2016) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50176994
Synonyms:
CHEMBL3813784
Type:
Small organic molecule
Emp. Form.:
C21H23NO5
Mol. Mass.:
369.411
SMILES:
O=C(COc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)O[C@H]1CCOC1 |r|
Structure:
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