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Target
Cyclin-dependent kinase 4/G1/S-specific cyclin-D2
Ligand
BDBM6655
Substrate
n/a
Meas. Tech.
ChEBML_1581924
IC50
100±n/a nM
Citation
 Schneider, P; Schneider, G De Novo Design at the Edge of Chaos. J Med Chem 59:4077-86 (2016) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4/G1/S-specific cyclin-D2
Synonyms:
Cyclin-dependent kinase 4/cyclin D2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1581924
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Component 2
Name:
G1/S-specific cyclin-D2
Synonyms:
CCND2 | CCND2_HUMAN | CDK6/cyclin D2 | G1/S-specific cyclin-D2
Type:
PROTEIN
Mol. Mass.:
33058.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108400
Residue:
289
Sequence:
MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
  
Inhibitor
Name:
BDBM6655
Synonyms:
3-(9-oxo-9H-fluoren-4-yl)-1-pyridin-2-ylurea | Diarylurea deriv. 15 | N-(9-Oxo-9H-fluoren-4-yl)-N -pyridin-2-ylurea
Type:
Small organic molecule
Emp. Form.:
C19H13N3O2
Mol. Mass.:
315.3254
SMILES:
O=C(Nc1ccccn1)Nc1cccc2C(=O)c3ccccc3-c12
Structure:
Search PDB for entries with ligand similarity: