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Target
Segment polarity protein dishevelled homolog DVL-1
Ligand
BDBM50177709
Substrate
n/a
Meas. Tech.
ChEMBL_1583392 (CHEMBL3816124)
Kd
1.3±n/a nM
Citation
 Choi, J; Ma, S; Kim, HY; Yun, JH; Heo, JN; Lee, W; Choi, KY; No, KT Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies. Bioorg Med Chem 24:3259-66 (2016) [PubMed]  Article 
Target
Name:
Segment polarity protein dishevelled homolog DVL-1
Synonyms:
DSH homolog 1 | DVL1 | DVL1_HUMAN | Dishevelled-1
Type:
PROTEIN
Mol. Mass.:
75195.46
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468588
Residue:
695
Sequence:
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
  
Inhibitor
Name:
BDBM50177709
Synonyms:
CHEMBL3814864
Type:
Small organic molecule
Emp. Form.:
C20H15Cl2NO6S
Mol. Mass.:
468.307
SMILES:
COc1cc(\C=C2/SC(=O)N(Cc3ccccc3Cl)C2=O)cc(Cl)c1OCC(O)=O
Structure:
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