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Target
Monocarboxylate transporter 1
Ligand
BDBM214702
Substrate
n/a
Meas. Tech.
ChEMBL_1581840 (CHEMBL3816459)
IC50
90±n/a nM
Citation
 Gurrapu, S; Jonnalagadda, SK; Alam, MA; Ronayne, CT; Nelson, GL; Solano, LN; Lueth, EA; Drewes, LR; Mereddy, VR Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents. Bioorg Med Chem Lett 26:3282-3286 (2016) [PubMed]  Article 
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1
Type:
Enzyme
Mol. Mass.:
53245.17
Organism:
Rattus norvegicus (Rat)
Description:
P53987
Residue:
494
Sequence:
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSSGDPAEEESPV
  
Inhibitor
Name:
BDBM214702
Synonyms:
US9296728, 25
Type:
Small organic molecule
Emp. Form.:
C24H19NO4
Mol. Mass.:
385.412
SMILES:
OC(=O)c1cc2ccc(cc2oc1=O)N(Cc1ccccc1)Cc1ccccc1
Structure:
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