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Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50174995
Substrate
n/a
Meas. Tech.
ChEMBL_1583938 (CHEMBL3815370)
EC50
2890±n/a nM
Citation
 Koura, M; Yamaguchi, Y; Kurobuchi, S; Sumida, H; Watanabe, Y; Enomoto, T; Matsuda, T; Okuda, A; Koshizawa, T; Matsumoto, Y; Shibuya, K Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency andß-selectivity of liver X receptor agonist. Bioorg Med Chem 24:3436-46 (2016) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50174995
Synonyms:
CHEMBL3814000
Type:
Small organic molecule
Emp. Form.:
C33H34F6N2O5
Mol. Mass.:
652.6239
SMILES:
CCCc1cc(ccc1Oc1cccc(CCN2C(=O)NC(C)(C2=O)c2ccc(OC(C)C)cc2)c1)C(O)(C(F)(F)F)C(F)(F)F
Structure:
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