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Target
Beta-glucuronidase
Ligand
BDBM50180321
Substrate
n/a
Meas. Tech.
ChEMBL_1583602 (CHEMBL3815689)
IC50
8300±n/a nM
Citation
 Taha, M; Sultan, S; Nuzar, HA; Rahim, F; Imran, S; Ismail, NH; Naz, H; Ullah, H Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potentß-glucuronidase inhibitors. Bioorg Med Chem 24:3696-704 (2016) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase)
Type:
Protein
Mol. Mass.:
74736.05
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
651
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
  
Inhibitor
Name:
BDBM50180321
Synonyms:
CHEMBL3814093
Type:
Small organic molecule
Emp. Form.:
C18H14FN3O4
Mol. Mass.:
355.3199
SMILES:
COc1ccc(O)c(\C=N\NC(=O)c2cnc3c(F)cccc3c2O)c1
Structure:
Search PDB for entries with ligand similarity: