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Target
Glucagon-like peptide 2 receptor
Ligand
BDBM50183657
Substrate
n/a
Meas. Tech.
ChEMBL_1586866 (CHEMBL3824486)
EC50
0.040000±n/a nM
Citation
 Wisniewski, K; Sueiras-Diaz, J; Jiang, G; Galyean, R; Lu, M; Thompson, D; Wang, YC; Croston, G; Posch, A; Hargrove, DM; Wisniewska, H; Laporte, R; Dwyer, JJ; Qi, S; Srinivasan, K; Hartwig, J; Ferdyan, N; Mares, M; Kraus, J; Alagarsamy, S; Rivière, PJ; Schteingart, CD Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide-2 (GLP-2) Analogues with Low Systemic Clearance. J Med Chem 59:3129-39 (2016) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 2 receptor
Synonyms:
GLP-2 receptor | GLP-2-R | GLP-2R | GLP2R_RAT | Glp2r | Glucagon-like peptide 2 receptor
Type:
PROTEIN
Mol. Mass.:
63128.29
Organism:
Rattus norvegicus
Description:
ChEMBL_116813
Residue:
550
Sequence:
MRPQPSPAVPSRCREAPVPRVRAQPVGIPEAQGPVPLHSQQMRLLWGPGRPFLALLLLVSIKQVTGSLLKETTQKWANYKEKCLEDLHNRLSGIFCNGTFDRYVCWPHSYPGNVSVPCPSYLPWWNAESPGRAYRHCLAQGTWQTRENTTDIWQDESECSENHSFRQNVDHYALLYTLQLMYTVGYSVSLISLFLALTLFLFLRKLHCTRNYIHMNLFASFILKVLAVLVKDMVSHNSYSKRPDDESGWMSYLSETSVSCRSVQVLLHYFVGTNHLWLLVEGLYLHTLLEPTVFPERRLWPKYLVVGWAFPMLFVIPWGFARAHLENTRCWATNGNLKIWWIIRGPMLLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLLLIPLLGVHEVLFTFFPDDQVQGFSKRIRLFIQLTLSSVHGFLVALQYGFANGEVKAELRKSWGRFLLARHWGCRTCVLGKNFRFLGKCSKKLSEGDGSETLQKLRFSTCSSHLASETLGDVGVQPHRGRGAWPRGSSLSESSEGDFTLANTMEEILEESEI
  
Inhibitor
Name:
BDBM50183657
Synonyms:
CHEMBL3823541
Type:
Small organic molecule
Emp. Form.:
C172H263N43O52
Mol. Mass.:
3765.1855
SMILES:
CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(N)=O |r|
Structure:
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