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Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM50184339
Substrate
n/a
Meas. Tech.
ChEMBL_1586879 (CHEMBL3824499)
IC50
13200±n/a nM
Citation
 Lv, W; Budke, B; Pawlowski, M; Connell, PP; Kozikowski, AP Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem 59:4511-25 (2016) [PubMed]  Article 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM50184339
Synonyms:
CHEMBL3824107
Type:
Small organic molecule
Emp. Form.:
C18H15N3O
Mol. Mass.:
289.3312
SMILES:
COc1ccc2c(c1)nc(-c1ccc(N)cc1)c1cccn21
Structure:
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