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Target
Patatin-like phospholipase domain-containing protein 2
Ligand
BDBM50185419
Substrate
n/a
Meas. Tech.
ChEMBL_1587882 (CHEMBL3826543)
IC50
700±n/a nM
Citation
 Roy, PP; D'Souza, K; Cuperlovic-Culf, M; Kienesberger, PC; Touaibia, M New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition. Eur J Med Chem 118:290-8 (2016) [PubMed]  Article 
Target
Name:
Patatin-like phospholipase domain-containing protein 2
Synonyms:
ATGL | Adipose triglyceride lipase | Calcium-independent phospholipase A2 | Desnutrin | IPLA2-zeta | PLPL2_HUMAN | PNPLA2 | Patatin-like phospholipase domain-containing protein 2 | Pigment epithelium-derived factor | TTS2 | TTS2.2 | Transport-secretion protein 2
Type:
PROTEIN
Mol. Mass.:
55319.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116817
Residue:
504
Sequence:
MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGVCLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTRVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQGYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALPGWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQLAGPAPLLSTPAPEARPVIGALGL
  
Inhibitor
Name:
BDBM50185419
Synonyms:
CHEMBL3823931
Type:
Small organic molecule
Emp. Form.:
C17H21N3O
Mol. Mass.:
283.3681
SMILES:
CN(C)C(=O)Nc1cccc(c1)-c1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: