Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50187505
Substrate
n/a
Meas. Tech.
ChEMBL_1590360 (CHEMBL3830508)
IC50
200±n/a nM
Citation
 Kritsi, E; Matsoukas, MT; Potamitis, C; Karageorgos, V; Detsi, A; Magafa, V; Liapakis, G; Mavromoustakos, T; Zoumpoulakis, P Exploring new scaffolds for angiotensin II receptor antagonism. Bioorg Med Chem 24:4444-4451 (2016) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50187505
Synonyms:
CHEMBL1332729
Type:
Small organic molecule
Emp. Form.:
C21H20ClN3O3
Mol. Mass.:
397.855
SMILES:
CN(Cc1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1)C(=O)CCC(O)=O
Structure:
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