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Target
Transient receptor potential cation channel subfamily V member 3
Ligand
BDBM50187697
Substrate
n/a
Meas. Tech.
ChEMBL_1591263 (CHEMBL3829796)
IC50
160±n/a nM
Citation
 Gomtsyan, A; Schmidt, RG; Bayburt, EK; Gfesser, GA; Voight, EA; Daanen, JF; Schmidt, DL; Cowart, MD; Liu, H; Altenbach, RJ; Kort, ME; Clapham, B; Cox, PB; Shrestha, A; Henry, R; Whittern, DN; Reilly, RM; Puttfarcken, PS; Brederson, JD; Song, P; Li, B; Huang, SM; McDonald, HA; Neelands, TR; McGaraughty, SP; Gauvin, DM; Joshi, SK; Banfor, PN; Segreti, JA; Shebley, M; Faltynek, CR; Dart, MJ; Kym, PR Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem 59:4926-47 (2016) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily V member 3
Synonyms:
TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3
Type:
Enzyme
Mol. Mass.:
90635.51
Organism:
Homo sapiens (Human)
Description:
Q8NET8
Residue:
790
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
  
Inhibitor
Name:
BDBM50187697
Synonyms:
CHEMBL3828278
Type:
Small organic molecule
Emp. Form.:
C16H15Cl2NO
Mol. Mass.:
308.202
SMILES:
O[C@H](c1ccccn1)C1(CCC1)c1ccc(Cl)c(Cl)c1 |r|
Structure:
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