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Target
DNA polymerase eta
Ligand
BDBM50104668
Substrate
n/a
Meas. Tech.
ChEMBL_1612845 (CHEMBL3854645)
IC50
50000±n/a nM
Citation
 Korzhnev, DM; Hadden, MK Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics. J Med Chem 59:9321-9336 (2016) [PubMed]  Article 
Target
Name:
DNA polymerase eta
Synonyms:
POLH | POLH_HUMAN | RAD30 | RAD30A | XPV
Type:
PROTEIN
Mol. Mass.:
78429.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1297317
Residue:
713
Sequence:
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHNSQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH
  
Inhibitor
Name:
BDBM50104668
Synonyms:
CHEMBL3593571
Type:
Small organic molecule
Emp. Form.:
C20H20O8
Mol. Mass.:
388.368
SMILES:
COC(=O)c1cc(OC)cc(OC)c1C(=O)c1coc(\C=C\C)c(OC)c1=O
Structure:
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