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Target
Potassium channel subfamily K member 18
Ligand
BDBM50197061
Substrate
n/a
Meas. Tech.
ChEMBL_1619068 (CHEMBL3861237)
EC50
18800±n/a nM
Citation
 Monteillier, A; Loucif, A; Omoto, K; Stevens, EB; Lainez, S; Saintot, PP; Cao, L; Pryde, DC Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K Bioorg Med Chem Lett 26:4919-4924 (2016) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 18
Synonyms:
KCNK18 | KCNKI_HUMAN | Potassium channel subfamily K member 18 | TRESK | TRIK | TWIK-related individual potassium channel | TWIK-related spinal cord potassium channel
Type:
PROTEIN
Mol. Mass.:
43672.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105638
Residue:
384
Sequence:
MEVSGHPQARRCCPEALGKLFPGLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEKFLEELCRILNCSETVVEDRKQDLQGHLQKVKPQWFNRTTHWSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPNFFLFFSIYIIVGMEIVFIAFKLVQNRLIDIYKNVMLFFAKGKFYHLVKK
  
Inhibitor
Name:
BDBM50197061
Synonyms:
CHEMBL3965023
Type:
Small organic molecule
Emp. Form.:
C17H19N5
Mol. Mass.:
293.3663
SMILES:
CC(C)(C)c1cccc(Nc2ccccc2-c2nnn[nH]2)c1
Structure:
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