Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 16
Ligand
BDBM50396070
Substrate
n/a
Meas. Tech.
ChEMBL_1619564 (CHEMBL3861733)
IC50
244000±n/a nM
Citation
 Norman, BH; McDermott, JS Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem 60:66-88 (2017) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 16
Synonyms:
CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | TNR16_HUMAN | Tumor necrosis factor receptor superfamily member 16 | p75 ICD
Type:
PROTEIN
Mol. Mass.:
45159.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_346884
Residue:
427
Sequence:
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
  
Inhibitor
Name:
BDBM50396070
Synonyms:
CHEMBL1397270
Type:
Small organic molecule
Emp. Form.:
C13H10N4O3
Mol. Mass.:
270.2435
SMILES:
Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C=O
Structure:
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