Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50197883
Substrate
n/a
Meas. Tech.
ChEMBL_1620070 (CHEMBL3862353)
Kd
274±n/a nM
Citation
 Simões, CJV; Almeida, ZL; Costa, D; Jesus, CSH; Cardoso, AL; Almeida, MR; Saraiva, MJ; Pinho E Melo, TMVD; Brito, RMM A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. Eur J Med Chem 121:823-840 (2016) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50197883
Synonyms:
CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Compound Tafamidis | US20240150297, Compound Tafamadis | Vyndaqel
Type:
Small organic molecule
Emp. Form.:
C14H7Cl2NO3
Mol. Mass.:
308.116
SMILES:
OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
Structure:
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