Target
Transthyretin
Ligand
BDBM50197882
Substrate
n/a
Meas. Tech.
ChEMBL_1620070 (CHEMBL3862353)
Kd
357±n/a nM
Citation
 Simões, CJVAlmeida, ZLCosta, DJesus, CSHCardoso, ALAlmeida, MRSaraiva, MJPinho E Melo, TMVDBrito, RMM A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. Eur J Med Chem 121:823-840 (2016) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50197882
Synonyms:
CHEMBL3959466
Type:
Small organic molecule
Emp. Form.:
C12H9ClO4
Mol. Mass.:
252.65
SMILES:
Cc1c(\C=C\c2ccc(Cl)o2)occ1C(O)=O
Structure:
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