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Target
Cathepsin B
Ligand
BDBM50197890
Substrate
n/a
Meas. Tech.
ChEBML_1620100
IC50
45±n/a nM
Citation
 Plebanek, E; Chevrier, F; Roy, V; Garenne, T; Lecaille, F; Warszycki, D; Bojarski, AJ; Lalmanach, G; Agrofoglio, LA Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S. Eur J Med Chem 121:12-20 (2016) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50197890
Synonyms:
CHEMBL3930949
Type:
Small organic molecule
Emp. Form.:
C15H17N7O
Mol. Mass.:
311.3418
SMILES:
COc1ccc(Nc2nc(nc(n2)N2CCNCC2)C#N)cc1
Structure:
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