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Target
Procathepsin L
Ligand
BDBM50197887
Substrate
n/a
Meas. Tech.
ChEBML_1620102
IC50
45±n/a nM
Citation
 Plebanek, E; Chevrier, F; Roy, V; Garenne, T; Lecaille, F; Warszycki, D; Bojarski, AJ; Lalmanach, G; Agrofoglio, LA Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S. Eur J Med Chem 121:12-20 (2016) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50197887
Synonyms:
CHEMBL3899928
Type:
Small organic molecule
Emp. Form.:
C16H19N7O
Mol. Mass.:
325.3684
SMILES:
O[C@@H](CNc1nc(nc(n1)N1CCNCC1)C#N)c1ccccc1 |r|
Structure:
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