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Target
Proteinase-activated receptor 4
Ligand
BDBM175970
Substrate
n/a
Meas. Tech.
ChEMBL_1621550 (CHEMBL3863833)
IC50
0.023±n/a nM
Citation
 Temple, KJ; Duvernay, MT; Maeng, JG; Blobaum, AL; Stauffer, SR; Hamm, HE; Lindsley, CW Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles. Bioorg Med Chem Lett 26:5481-5486 (2016) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM175970
Synonyms:
US10047103, 3 | US9605024, Example 3 | US9688695, 3
Type:
Small organic molecule
Emp. Form.:
C24H18N4O4S2
Mol. Mass.:
490.554
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccccc3)cc(OC)cc2o1
Structure:
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