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Target
Polypeptide N-acetylgalactosaminyltransferase 2
Ligand
BDBM50200114
Substrate
n/a
Meas. Tech.
ChEMBL_1621820 (CHEMBL3864103)
IC50
696000±n/a nM
Citation
 Wang, Y; Zhu, J; Zhang, L Discovery of Cell-Permeable O-GlcNAc Transferase Inhibitors via Tethering in Situ Click Chemistry. J Med Chem 60:263-272 (2017) [PubMed]  Article 
Target
Name:
Polypeptide N-acetylgalactosaminyltransferase 2
Synonyms:
GALNT2 | GALT2_HUMAN | GalNAc-T2 | Polypeptide GalNAc transferase 2 | Polypeptide N-acetylgalactosaminyltransferase 2 | Polypeptide N-acetylgalactosaminyltransferase 2 soluble form | Protein-UDP acetylgalactosaminyltransferase 2 | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 | pp-GaNTase 2
Type:
PROTEIN
Mol. Mass.:
64746.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115316
Residue:
571
Sequence:
MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ
  
Inhibitor
Name:
BDBM50200114
Synonyms:
CHEMBL3920498
Type:
Small organic molecule
Emp. Form.:
C20H16N4O
Mol. Mass.:
328.3672
SMILES:
CC(=O)Nc1ccc(cc1)-n1cc(nn1)-c1ccc2ccccc2c1
Structure:
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