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Target
Probable G-protein coupled receptor 142
Ligand
BDBM50381477
Substrate
n/a
Meas. Tech.
ChEMBL_1623128 (CHEMBL3865480)
EC50
23±n/a nM
Citation
 Guo, L; Parker, DL; Zang, Y; Sweis, RF; Liu, W; Sherer, EC; Buist, N; Terebetski, J; Kelly, T; Bugianesi, R; Priest, BT; Dingley, KH; Li, X; Mitelman, S; Salituro, G; Trujillo, ME; Pachanski, M; Kirkland, M; Powles, MA; Eiermann, GJ; Feng, Y; Shang, J; Howard, AD; Ujjainwalla, F; Sinz, CJ; Debenham, JS; Edmondson, SD; Nargund, RP; Hagmann, WK; Li, D Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes. ACS Med Chem Lett 7:1107-1111 (2016) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
GP142_MOUSE | Gpr142
Type:
PROTEIN
Mol. Mass.:
40779.27
Organism:
Mus musculus
Description:
ChEMBL_985965
Residue:
365
Sequence:
MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
  
Inhibitor
Name:
BDBM50381477
Synonyms:
CHEMBL2017410
Type:
Small organic molecule
Emp. Form.:
C25H22N6O2
Mol. Mass.:
438.4812
SMILES:
COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc3ccccc23)nn1
Structure:
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