Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 6
Ligand
BDBM50202483
Substrate
n/a
Meas. Tech.
ChEMBL_1624421 (CHEMBL3866833)
IC50
34±n/a nM
Citation
 Wang, P; Huang, J; Wang, K; Gu, Y New palbociclib analogues modified at the terminal piperazine ring and their anticancer activities. Eur J Med Chem 122:546-556 (2016) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM50202483
Synonyms:
CHEMBL3954429
Type:
Small organic molecule
Emp. Form.:
C26H33N7O2
Mol. Mass.:
475.5859
SMILES:
CCN1CCN(CC1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1
Structure:
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