Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 4
Ligand
BDBM50202485
Substrate
n/a
Meas. Tech.
ChEMBL_1624420 (CHEMBL3866832)
IC50
13±n/a nM
Citation
 Wang, P; Huang, J; Wang, K; Gu, Y New palbociclib analogues modified at the terminal piperazine ring and their anticancer activities. Eur J Med Chem 122:546-556 (2016) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50202485
Synonyms:
CHEMBL3905696
Type:
Small organic molecule
Emp. Form.:
C30H40N8O4
Mol. Mass.:
576.6898
SMILES:
COCCCNCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1
Structure:
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