Reaction Details Report a problem with these data
Target
Free fatty acid receptor 4
Ligand
BDBM50203673
Substrate
n/a
Meas. Tech.
ChEMBL_1625791 (CHEMBL3868260)
EC50
81±n/a nM
Citation
 Lombardo, M; Bender, K; London, C; Plotkin, MA; Kirkland, M; Mane, J; Pachanski, M; Geissler, W; Cummings, J; Habulihaz, B; Akiyama, TE; Di Salvo, J; Madeira, M; Pols, J; Powles, MA; Finley, MF; Johnson, E; Roussel, T; Uebele, VN; Crespo, A; Leung, D; Alleyne, C; Trusca, D; Lei, Y; Howard, AD; Ujjainwalla, F; Tata, JR; Sinz, CJ Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects. Bioorg Med Chem Lett 26:5724-5728 (2016) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 4
Synonyms:
FFAR4_MOUSE | Ffar4 | Free fatty acid receptor 4 | G-protein coupled receptor GT01 | Gpr120 | O3far1 | Omega-3 fatty acid receptor 1
Type:
PROTEIN
Mol. Mass.:
40828.60
Organism:
Mus musculus
Description:
ChEMBL_1454435
Residue:
361
Sequence:
MSPECAQTTGPGPSHTLDQVNRTHFPFFSDVKGDHRLVLSVVETTVLGLIFVVSLLGNVCALVLVARRRRRGATASLVLNLFCADLLFTSAIPLVLVVRWTEAWLLGPVVCHLLFYVMTMSGSVTILTLAAVSLERMVCIVRLRRGLSGPGRRTQAALLAFIWGYSALAALPLCILFRVVPQRLPGGDQEIPICTLDWPNRIGEISWDVFFVTLNFLVPGLVIVISYSKILQITKASRKRLTLSLAYSESHQIRVSQQDYRLFRTLFLLMVSFFIMWSPIIITILLILIQNFRQDLVIWPSLFFWVVAFTFANSALNPILYNMSLFRNEWRKIFCCFFFPEKGAIFTDTSVRRNDLSVISS
  
Inhibitor
Name:
BDBM50203673
Synonyms:
CHEMBL3972973
Type:
Small organic molecule
Emp. Form.:
C19H17ClNO3S
Mol. Mass.:
374.861
SMILES:
OC(=O)CCCOc1ccc(cc1)-c1cc(ccc1Cl)-[n+]1ccsc1
Structure:
Search PDB for entries with ligand similarity: