Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50205566
Substrate
n/a
Meas. Tech.
ChEMBL_1628396 (CHEMBL3870981)
Ki
8489±n/a nM
Citation
 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII. Bioorg Med Chem Lett 27:86-89 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50205566
Synonyms:
CHEMBL3947267
Type:
Small organic molecule
Emp. Form.:
C30H32N6O4S
Mol. Mass.:
572.678
SMILES:
CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2cccc(c2)-c2nnn[nH]2)C(=O)CC(C)(C)C1)c1ccc(cc1)S(N)(=O)=O |c:6,11|
Structure:
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