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Target
Transthyretin
Ligand
BDBM50197883
Substrate
n/a
Meas. Tech.
ChEMBL_1628944 (CHEMBL3871570)
IC50
1550±n/a nM
Citation
 Kim, B; Park, H; Lee, SK; Park, SJ; Koo, TS; Kang, NS; Hong, KB; Choi, S Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors. Eur J Med Chem 123:777-787 (2016) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50197883
Synonyms:
CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Compound Tafamidis | Vyndaqel
Type:
Small organic molecule
Emp. Form.:
C14H7Cl2NO3
Mol. Mass.:
308.116
SMILES:
OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
Structure:
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