Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50206385
Substrate
n/a
Meas. Tech.
ChEMBL_1628944 (CHEMBL3871570)
IC50
2060±n/a nM
Citation
 Kim, B; Park, H; Lee, SK; Park, SJ; Koo, TS; Kang, NS; Hong, KB; Choi, S Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors. Eur J Med Chem 123:777-787 (2016) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50206385
Synonyms:
CHEMBL3976323
Type:
Small organic molecule
Emp. Form.:
C19H14N2O3
Mol. Mass.:
318.3261
SMILES:
Cc1cc(cc(C)c1O)C#Cc1ccc2cc(ccc2n1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: