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Target
D(3) dopamine receptor
Ligand
BDBM50207156
Substrate
n/a
Meas. Tech.
ChEMBL_1630050 (CHEMBL3872756)
Ki
0.310000±n/a nM
Citation
 Chen, XW; Sun, YY; Fu, L; Li, JQ Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. Eur J Med Chem 123:332-353 (2016) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50207156
Synonyms:
CHEMBL3938210 | US9550741, I-3
Type:
Small organic molecule
Emp. Form.:
C24H31N5OS
Mol. Mass.:
437.601
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccc[nH]1 |r,wU:3.2,wD:6.6,(22.96,-24.14,;22.24,-22.76,;23.01,-21.42,;24.55,-21.42,;25.32,-20.09,;26.86,-20.09,;27.63,-21.42,;29.17,-21.42,;29.94,-20.09,;31.48,-20.09,;32.25,-21.42,;33.79,-21.42,;34.56,-20.09,;33.79,-18.75,;32.25,-18.75,;36.1,-20.09,;37.02,-21.32,;38.46,-20.86,;38.46,-19.32,;39.65,-18.3,;39.29,-16.8,;37.85,-16.29,;36.72,-17.32,;37.02,-18.86,;26.86,-22.76,;25.32,-22.76,;20.7,-22.66,;19.88,-21.38,;18.39,-21.79,;18.29,-23.33,;19.73,-23.89,)|
Structure:
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