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Target
D(3) dopamine receptor
Ligand
BDBM50207144
Substrate
n/a
Meas. Tech.
ChEMBL_1630050 (CHEMBL3872756)
Ki
0.180000±n/a nM
Citation
 Chen, XW; Sun, YY; Fu, L; Li, JQ Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. Eur J Med Chem 123:332-353 (2016) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50207144
Synonyms:
CHEMBL3940712 | US9550741, IV-11
Type:
Small organic molecule
Emp. Form.:
C27H35N5OS
Mol. Mass.:
477.665
SMILES:
O=C(NCc1ccccc1)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1 |r,wU:11.11,wD:14.15,(26.22,-29.78,;25.55,-28.45,;24.01,-28.34,;23.14,-29.63,;21.6,-29.58,;20.94,-28.19,;19.4,-28.09,;18.58,-29.42,;19.25,-30.75,;20.78,-30.86,;26.32,-27.12,;27.86,-27.12,;28.63,-25.78,;30.16,-25.78,;30.93,-27.12,;32.47,-27.12,;33.24,-25.78,;34.77,-25.78,;35.54,-27.12,;37.08,-27.12,;37.85,-25.78,;37.08,-24.45,;35.54,-24.45,;39.39,-25.78,;40.26,-27.02,;41.68,-26.55,;41.68,-25.01,;42.81,-23.99,;42.5,-22.45,;41.01,-21.99,;39.95,-23.02,;40.26,-24.5,;30.16,-28.45,;28.63,-28.45,)|
Structure:
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