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Target
Neuropilin-1
Ligand
BDBM50208993
Substrate
n/a
Meas. Tech.
ChEMBL_1633629 (CHEMBL3876421)
IC50
890±n/a nM
Citation
 Grabowska, K; Puszko, AK; Lipinski, PF; Laskowska, AK; Wilenska, B; Witkowska, E; Perret, GY; Misicka, A Structure-activity relationship study of a small cyclic peptide H-c[Lys-Pro-Glu]-Arg-OH: a potent inhibitor of Vascular Endothelial Growth Factor interaction with Neuropilin-1. Bioorg Med Chem 25:597-602 (2017) [PubMed]  Article 
Target
Name:
Neuropilin-1
Synonyms:
CD_antigen=CD304 | NRP1_RAT | Neuropilin-1 | Nrp1 | Vascular endothelial cell growth factor 165 receptor
Type:
PROTEIN
Mol. Mass.:
103073.15
Organism:
Rattus norvegicus
Description:
ChEMBL_109427
Residue:
922
Sequence:
MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA
  
Inhibitor
Name:
BDBM50208993
Synonyms:
CHEMBL3885318
Type:
Small organic molecule
Emp. Form.:
C44H76N16O12
Mol. Mass.:
1021.1742
SMILES:
NCCCC[C@@H]1NC(=O)[C@H](CCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)CCCCNC(=O)CC[C@H](NC(=O)[C@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Structure:
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