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Target
Mitogen-activated protein kinase kinase kinase 7
Ligand
BDBM50209656
Substrate
n/a
Meas. Tech.
ChEMBL_1633896 (CHEMBL3876688)
IC50
25±n/a nM
Citation
 Tan, L; Gurbani, D; Weisberg, EL; Hunter, JC; Li, L; Jones, DS; Ficarro, SB; Mowafy, S; Tam, CP; Rao, S; Du, G; Griffin, JD; Sorger, PK; Marto, JA; Westover, KD; Gray, NS Structure-guided development of covalent TAK1 inhibitors. Bioorg Med Chem 25:838-846 (2017) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase kinase kinase 7
Synonyms:
M3K7_HUMAN | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TAK1/TAB1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1 (TAK1)
Type:
Protein
Mol. Mass.:
67199.89
Organism:
Homo sapiens (Human)
Description:
O43318
Residue:
606
Sequence:
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
  
Inhibitor
Name:
BDBM50209656
Synonyms:
CHEMBL3883823
Type:
Small organic molecule
Emp. Form.:
C23H24Cl2N6O2
Mol. Mass.:
487.382
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3ccccc3NC(=O)CCl)n2)cc1
Structure:
Search PDB for entries with ligand similarity: