Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50210268
Substrate
n/a
Meas. Tech.
ChEMBL_1634637 (CHEMBL3877535)
Ki
133±n/a nM
Citation
 Rui, M; Rossi, D; Marra, A; Paolillo, M; Schinelli, S; Curti, D; Tesei, A; Cortesi, M; Zamagni, A; Laurini, E; Pricl, S; Schepmann, D; Wunsch, B; Urban, E; Pace, V; Collina, S Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents. Eur J Med Chem 124:649-665 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50210268
Synonyms:
CHEMBL3984952
Type:
Small organic molecule
Emp. Form.:
C27H45N3O3
Mol. Mass.:
459.6645
SMILES:
COc1ccc(C)cc1NC(=O)OC1CC2CCCC(C1)N2CCCCCCCCCCN |TLB:22:21:16.18.17:20.13.14,THB:12:13:21:16.18.17|
Structure:
Search PDB for entries with ligand similarity: