Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50210331
Substrate
n/a
Meas. Tech.
ChEMBL_1634596 (CHEMBL3877494)
Ki
6.9±n/a nM
Citation
 Rui, M; Rossi, D; Marra, A; Paolillo, M; Schinelli, S; Curti, D; Tesei, A; Cortesi, M; Zamagni, A; Laurini, E; Pricl, S; Schepmann, D; Wunsch, B; Urban, E; Pace, V; Collina, S Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents. Eur J Med Chem 124:649-665 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50210331
Synonyms:
CHEMBL3913410
Type:
Small organic molecule
Emp. Form.:
C26H31NO
Mol. Mass.:
373.5304
SMILES:
CC(O)(CCN1CCC(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: