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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50210916
Substrate
n/a
Meas. Tech.
ChEMBL_1635519 (CHEMBL3878417)
IC50
510±n/a nM
Citation
 Saito, R; Hoshi, M; Kato, A; Ishikawa, C; Komatsu, T Green fluorescent protein chromophore derivatives as a new class of aldose reductase inhibitors. Eur J Med Chem 125:965-974 (2017) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50210916
Synonyms:
CHEMBL3936476
Type:
Small organic molecule
Emp. Form.:
C14H14N2O4
Mol. Mass.:
274.272
SMILES:
COc1ccc(\C=C2/N=C(C)N(CC(O)=O)C2=O)cc1 |t:8|
Structure:
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