Reaction Details Report a problem with these data
Target
Somatostatin receptor type 1/2/3/4/5
Ligand
BDBM50213869
Substrate
n/a
Meas. Tech.
ChEBML_200348
IC50
12000±n/a nM
Citation
  TBA Bioorg Med Chem Lett 6:1667-1672 (1996)   
Target
Name:
Somatostatin receptor type 1/2/3/4/5
Synonyms:
Somatostatin receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 200351
Components:
This complex has 5 components.
Component 1
Name:
Somatostatin receptor type 1
Synonyms:
SOMATOSTATIN SST1 | SRIF-2 | SS1R | SSR1_RAT | Somatostatin receptor | Somatostatin receptor type 1 | Sstr1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42752.93
Organism:
RAT
Description:
SOMATOSTATIN SST1 SSTR1 RAT::P28646
Residue:
391
Sequence:
MFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL
  
Component 2
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SSR3_RAT | Somatostatin receptor | Somatostatin receptor 3 | Somatostatin receptor type 3 | Sstr3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47161.54
Organism:
RAT
Description:
SOMATOSTATIN SST3 SSTR3 RAT::P30936
Residue:
428
Sequence:
MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQPGPSGQQQRPCTGTAKEQQLLPQEATAGDKASTLSHL
  
Component 3
Name:
Somatostatin receptor type 4
Synonyms:
SOMATOSTATIN SST4 | SSR4_RAT | Somatostatin receptor | Somatostatin receptor type 4 | Sstr4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42096.84
Organism:
RAT
Description:
SOMATOSTATIN SST4 SSTR4 RAT::P30937
Residue:
384
Sequence:
MNTPATLPLGGEDTTWTPGINASWAPDEEEDAVRSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGPGCICPPLPCQQEPMQAEPACKRVPFTKTTTF
  
Component 4
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS2R | SSR2_RAT | Somatostatin receptor | Somatostatin receptor 2 | Somatostatin receptor type 2 | Sstr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41212.21
Organism:
RAT
Description:
SOMATOSTATIN SST2 SSTR2 RAT::P30680
Residue:
369
Sequence:
MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Component 5
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SSR5_RAT | Somatostatin receptor | Somatostatin receptor type 5 | Sstr5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39986.50
Organism:
RAT
Description:
SOMATOSTATIN SST5 SSTR5 RAT::P30938
Residue:
363
Sequence:
MEPLSLASTPSWNASAASSGNHNWSLVGSASPMGARAVLVPVLYLLVCTVGLSGNTLVIYVVLRHAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKMASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSEPKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRRGYGMEDADAIEPRPDKSGRPQATLPTRSCEANGLMQTSRI
  
Inhibitor
Name:
BDBM50213869
Synonyms:
CHEMBL3037859
Type:
Small organic molecule
Emp. Form.:
C36H46N4O2
Mol. Mass.:
566.776
SMILES:
[H][C@@]1(OCc2ccccc2)C2CN(CCCCCCN)C[C@H](N2CCc2c[nH]c3ccccc23)[C@@]1([H])OCc1ccccc1 |TLB:36:34:22:12.11.20,THB:13:12:22:34.1,2:1:22:12.11.20|
Structure:
Search PDB for entries with ligand similarity: