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Target
Phosphoglycerate kinase 1/2
Ligand
BDBM50216217
Substrate
n/a
Meas. Tech.
ChEMBL_155738 (CHEMBL759843)
Kd
6000±n/a nM
Citation
 Williams, DM; Jakeman, DL; Vyle, JS; Williamson, MP; Blackburn, GM Synthesis and binding of stable bisubstrate ligands for phosphoglycerate kinase. Bioorg Med Chem Lett 8:2603-8 (1998) [PubMed]  Article 
Target
Name:
Phosphoglycerate kinase 1/2
Synonyms:
Phosphoglycerate kinase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 155738
Components:
This complex has 2 components.
Component 1
Name:
Phosphoglycerate kinase 2
Synonyms:
PGK2 | PGK2_HUMAN | PGKB | Phosphoglycerate kinase 2 | Phosphoglycerate kinase, testis specific
Type:
PROTEIN
Mol. Mass.:
44805.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104832
Residue:
417
Sequence:
MSLSKKLTLDKLDVRGKRVIMRVDFNVPMKKNQITNNQRIKASIPSIKYCLDNGAKAVVLMSHLGRPDGVPMPDKYSLAPVAVELKSLLGKDVLFLKDCVGAEVEKACANPAPGSVILLENLRFHVEEEGKGQDPSGKKIKAEPDKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPHKASGFLMKKELDYFAKALENPVRPFLAILGGAKVADKIQLIKNMLDKVNEMIIGGGMAYTFLKVLNNMEIGASLFDEEGAKIVKDIMAKAQKNGVRITFPVDFVTGDKFDENAQVGKATVASGISPGWMGLDCGPESNKNHAQVVAQARLIVWNGPLGVFEWDAFAKGTKALMDEIVKATSKGCITVIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKILPGVEALSNM
  
Component 2
Name:
Phosphoglycerate kinase 1
Synonyms:
Cell migration-inducing gene 10 protein | PGK1 | PGK1_HUMAN | PGKA | PGKA | PRP 2 | Phosphoglycerate kinase 1 | Primer recognition protein 2
Type:
PROTEIN
Mol. Mass.:
44619.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104832
Residue:
417
Sequence:
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
  
Inhibitor
Name:
BDBM50216217
Synonyms:
CHEMBL1160562
Type:
Small organic molecule
Emp. Form.:
C15H22F4N5O12P3
Mol. Mass.:
633.2764
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)C(F)(F)CCCC(F)(F)P(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: