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Target
D(2) dopamine receptor
Ligand
BDBM50218415
Substrate
n/a
Meas. Tech.
ChEMBL_60529 (CHEMBL674940)
Ki
1259±n/a nM
Citation
 Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Hadley, MS; Jeffrey, P; Johnson, CN; Macdonald, GJ; Nash, DJ; Riley, GJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Wood, M Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett 10:2553-5 (2000) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50218415
Synonyms:
CHEMBL445111
Type:
Small organic molecule
Emp. Form.:
C29H32N4O
Mol. Mass.:
452.5906
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCc3ccc(cc3CC2)C#N)CC1)c1ccnc2ccccc12 |wU:3.2,wD:6.6,(23.4,-13.46,;23.24,-11.92,;21.83,-11.3,;20.58,-12.2,;20.74,-13.74,;19.48,-14.65,;18.08,-14.02,;16.82,-14.93,;15.42,-14.3,;14.16,-15.21,;12.76,-14.58,;11.39,-15.28,;11.09,-16.8,;9.59,-17.08,;9.08,-18.52,;10.07,-19.71,;11.59,-19.41,;12.09,-17.96,;13.63,-17.92,;14.56,-16.7,;9.55,-21.16,;9.01,-22.63,;17.92,-12.48,;19.15,-11.57,;24.49,-11.02,;24.32,-9.48,;25.57,-8.58,;26.97,-9.21,;27.13,-10.74,;28.54,-11.36,;28.71,-12.9,;27.46,-13.81,;26.06,-13.18,;25.89,-11.64,)|
Structure:
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