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Target
Penicillin-binding protein 3
Ligand
BDBM50218765
Substrate
n/a
Meas. Tech.
ChEMBL_153204 (CHEMBL763706)
IC50
>663000±n/a nM
Citation
 Chen, Z; Demuth, TP; Wireko, FC Stereoselective synthesis and antibacterial evaluation of 4-amido-isothiazolidinone oxides. Bioorg Med Chem Lett 11:2111-5 (2001) [PubMed]  Article 
Target
Name:
Penicillin-binding protein 3
Synonyms:
Penicillin-binding protein 3
Type:
PROTEIN
Mol. Mass.:
77276.93
Organism:
Staphylococcus aureus
Description:
ChEMBL_100046
Residue:
691
Sequence:
MLKRLKEKSNDEIVQNTINKRINFIFGVIVFIFAVLVLRLGYLQIAQGSHYKQIIKNDENITVNESVPRGRILDRNGKVLVDNASKMAITYTRGRKTTQSEMLDTAEKLSKLIKMDTKKITERDKKDFWIQLHPKKAKAMMTKEQAMLADGSIKQDQYDKQLLSKIGKSQLDELSSKDLQVLAIFREMNAGTVLDPQMIKNEDVSEKEYAAVSQQLSKLPGVNTSMDWDRKYPYGDTLRGIFGDVSTPAEGIPKELTEHYLSKGYSRNDRVGKSYLEYQYEDVLRGKKKEMKYTTDKSGKVTSSEVLNPGARGQDLKLTIDIDLQKEVEALLDKQIKKLRSQGAKDMDNAMMVVQNPKNGDILALAGKQINKSGKMTDYDIGTFTSQFAVGSSVKGGTLLAGYQNKAIKVGETMVDEPLHFQGGLTKRSYFNKNGHVTINDKQALMRSSNVYMFKTALKLAGDPYYSGMALPSDISSPAQKLRRGLNQVGLGVKTGIDLPNETRGQIEPLTNNPGNYLDLSIGQYDTYTPLQLSQYVSTIANDGYRIQPHIGLTIHESTNKDEVGPLKKKINGTVLNKVNNTEKEIKQIQEGFKMAFNDKDGTGYVSFKDTVVPTAGKTGTAEVFQNGEPRVNSTYIGYAPIDDPKLAFSIVYTNQPVPPPWLTGGDLGRDVINYYFKQLGKDDKNKDKDK
  
Inhibitor
Name:
BDBM50218765
Synonyms:
CHEMBL66962
Type:
Small organic molecule
Emp. Form.:
C13H13ClN2O7S
Mol. Mass.:
376.77
SMILES:
CC(N1C(=O)C(CS1(=O)=O)NC(=O)Oc1ccc(Cl)cc1)C(O)=O
Structure:
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