Reaction Details
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Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50221743
Substrate
n/a
Meas. Tech.
ChEMBL_63920 (CHEMBL677327)
IC50
>414000±n/a nM
Citation
Hazra, B; Pore, V; Dey, S; Datta, S; Darokar, M; Saikia, D; Khanuja, SP; Thakur, A Bile acid amides derived from chiral amino alcohols: novel antimicrobials and antifungals. Bioorg Med Chem Lett 14:773-7 (2004) [PubMed] Article More Info.:
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
Inhibitor
Name:
BDBM50221743
Synonyms:
CHEMBL352152
Type:
Small organic molecule
Emp. Form.:
C33H50N2O8
Mol. Mass.:
602.7587
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])C(O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)[C@H](C)CCC(=O)N[C@@H](CO)[C@@H](O)c1ccc(cc1)[N+]([O-])=O
Structure:
